Stocks making the biggest moves premarket: Twilio, Boeing, Novo Nordisk, CSX and more

cnbc.com:

These are some of the stocks posting the largest moves in premarket trading:

Boeing — The airplane maker slipped 1.3% after preliminary fourth-quarter financial results reflected ongoing struggles. Boeing said it expects to report a loss of $5.46 per share for the fourth quarter on revenue of $15.2 billion, less than analysts' expectations, according to LSEG estimates. Boeing, which has not posted an annual profit since 2018, said it likely burned through $3.5 billion in cash during the quarter, partly due to a labor strike and new workforce agreement.

Novo Nordisk — U.S.-listed shares jumped 14% after the Danish pharmaceutical maker said an early-stage trial for its once weekly amycretin obesity drug resulted in average weight reduction of 22% in obese and overweight patients after 36 weeks. Patients treated with the placebo saw 2% weight gain during the same period.  

Twilio — The cloud communications software maker issued an optimistic forecast for the next few years at a Thursday investor event, leading shares to rally almost 18%. Twilio said its adjusted operating margin will reach as high as 22% in 2027, above the Wall Street consensus and the latest quarter's 16.1%. Baird upgraded the stock to an outperform rating from neutral and said it came away from the company's event confident ahead of its fourth-quarter results.

CSX — The Jacksonville, Florida-basedrailroad slipped 3.5% after saying revenue fell last quarter due to a lower fuel surcharge and smaller coal revenue. CSX posted in-line earnings of 42 cents a share, excluding one-time items, which analysts polled by FactSet had expected. Revenue of $3.54 billion came in below the $3.56 billion forecast by analysts from FactSet.

Texas Instruments — Shares slumped